Those who practice medicine typically aspire to the positive aspects of the culture of medical humanism: striving to provide excellent care, adhering to ethical standards and contributing to the greater good. Unfortunately, necessary stressors, such as clinically and emotionally challenging patients, unpredictable workloads and documentation burden, and unnecessary stressors, such as difficult systems and teams threaten the persistence and wellness of even the most dedicated physicians. The STREAM program was developed to help individuals incorporate both personal and system-level changes in areas of well-being, systems improvement, resilience and meaning in work.